Exogenous damage causes cell DNA damage through mediated reactive oxygen levels
نویسندگان
چکیده
منابع مشابه
Reactive oxygen species and oxidative DNA damage.
Reactive oxygen species (ROS) such as the superoxide anion radical (O2.-) hydrogen peroxide (H2O2) and hydroxyl radical (.OH) have been implicated in the pathophysiology of various states, including ischemia reperfusion injury, haemorrhagic shock, atherosclerosis, heart failure, acute hypertension and cancer. The free radicals, nitric oxide (NO) and O2.- react to form peroxynitrite (ONOO-), a p...
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Oxidative Modification of LDL Although LDL is essential to deliver cholesterol to tissues, increased LDL cholesterol is associated with increased risk of cardiovascular disease. Oxidative modification of LDL promotes recruitment and retention of monocytes3 with formation of fatty streaks, the earliest lesions in atherosclerosis.4 Both macrophages and vascular smooth muscle cells (VSMCs) bind ox...
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UNLABELLED BACKGROUND The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of oxidative stress have been found in tissues from children with autism spectrum disorders, evidence for damage to mtDNA is lacking. FINDINGS mtDNA deletions were evaluated in peripheral blood monoc...
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ژورنال
عنوان ژورنال: E3S Web of Conferences
سال: 2019
ISSN: 2267-1242
DOI: 10.1051/e3sconf/201913101018